Serge Ravaine, in Anisotropic Particle Assemblies, 2018 1.4.1.4 Geometrical confinement Where there is potential for shear degradation, lower solution concentrations and lower flow-rates can also reduce this unwanted effect. > 2 000 000) the use of larger packing size (e.g., 20 μm) should be considered. For very high molecular weight polymers (ca. 10 000–100 000) and 3 μm packings can be used for lower molecular weights. The 10 μm material is appropriate for a very wide range of molecular weights but additional efficiency can be obtained by using 5 μm packing for polymers with moderate molecular weights (ca. However, when working with high molecular weight polymers, the higher linear flow velocity associated with the smaller packing sizes can cause shear degradation of the polymer and the particle size must be selected to suit the molecular weight of the sample polymer. Davies, in Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, 2016 Column Packing Size and Shear Effectsįor some time the normal column packing particle size available has been around 10 μm but, in common with other forms of liquid chromatography, there has been a trend towards increasing the efficiency by producing smaller particle size packings.
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